Autonomous actions of the human growth hormone long-range enhancer

Autonomous actions of the human growth hormone long-range enhancer

The human growth hormone (hGH) gene is controlled by a long-range enhancer, HSI, located 14.5 kb 5' to the hGH promoter. HSI establishes a domain of noncoding transcription that is 'looped' to the hGH promoter as an essential step in initiating hGH gene expression. Thus, defining how HSI generates its domain of noncoding transcription is central to understanding its long-range function. Here, w...

Long - range enhancer - promoter interactions :

DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.

Locus control regions (LCRs) comprise sets of DNA elements capable of establishing autonomous chromatin domains that support robust and physiologically appropriate expression of target genes, often working over extensive distances. Human growth hormone (hGH-N) expression in the pituitary is under the regulation of a well characterized LCR containing four DNase I hypersensitive sites (HSs). The ...

The Hypophyseal Growth Hormone, Nature and Actions

many formulae and figures. Its many chapter subheadings give the book its rather terse, outline form. A discussion of methods of isolation, characterization, and determination of purity is followed by successive chapters dealing with reaction rates as a function of substrate concentration, inhibitor action, temperature, and pH. Thermodynamic concepts are well developed in chapters on energetics...

Role of SOCS2 in growth hormone actions.

Growth hormone (GH) has numerous effects in the body and is most commonly known for its role in regulating metabolism and body growth. Because GH is involved in many aspects of cell function, its signaling is tightly controlled by several pathways at both the extracellular and intracellular level. Suppressor of cytokine signaling-2 (SOCS2) is one such intracellular regulator of GH signal transd...